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By blocking HAI-1, Dihexa allows endogenous HGF to remain active for longer periods and at higher effective concentrations

Nanoscale 2 , 114121 (2010)

GSTO1 knockdown as well as the small-molecule GSTO1 inhibitor C1-27 also caused downregulation of the Wnt inhibitor Dickkopf 1 ( DKK1 ), thombospondin 1 ( THBS1 ), the cysteine-rich angiogenic inducer CYR61 and caveolae scaffolding proteins CAV1 and CAV2 , among others