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This background suggests that the optimal condition for a drug to be more efficient in carrying out its therapeutic action would be to cross a BBB with good vascular integrity and without further damage in the neuronal functional state

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Ghrelin binds to and activates the growth hormone secretagogue receptor in the brain

Oxidative DNA damage also activates poly(ADP-ribose) polymerase-1 (PARP-1), which can rapidly deplete intracellular NAD + [15, 16]

Dietary supplements.