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The distribution and partition coefficients are in general agreement with the pK a of sitagliptin (7.7) (Charoo NA, et al ., 2022)
In the in vivo experiments, the authors treated the streptozotocin-induced DM mice with exendin-4 at 10 nmol/kg for 4 weeks and found that exendin-4 promoted the peripheral nerve function as reflected by improved current perception threshold and motor and sensory nerve conduction velocity
Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15
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Acknowledgments The authors gratefully acknowledge the Centre for Diabetes, School of Biomedical Sciences, Ulster University (UK)
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