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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations
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doi: 10.1056/NEJMoa2206038 83 US National Institutes of Health
Biomed Pharmacother 127:110205
4.3 Applications Collagen-based supplements are increasingly incorporated into functional foods, such as anti-hypertensive beverages and dietary supplements, owing to their low molecular weight and high bioavailability, which enable sustained ACE inhibitory effects [148, 149]
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