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Polymeric NPs can either breach the BBB via surface functionalization, for instance using Abs directed against endothelial cell surface receptors leveraging the RMT route, or negatively charged on their surface, for intravenous applications, as described above in sections Different mechanisms of transport across the blood-brain barrier and Effect of nanoparticles surface charge and also reviewed in Saraiva et al
This cycle repeats until their capacity is also severely diminished
Gip mng tay, mng chn chc khe, tc bng mt v gim rng tc
13, Sept
10.1002/hep.26667 30
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