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SIRT1, an NAD + -dependent class III histone deacetylase, regulates hepatic lipid metabolism through deacetylation of multiple transcription factors and metabolic enzymes, exerting a bidirectional effect on lipid homeostasis by inhibiting fat synthesis and promoting fatty acid oxidation

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"The healthcare professional who is responsible for providing the prescription should take all of these factors into consideration when presenting medication options," he adds The bottom line Both phentermine and Wegovy can be useful weight-loss medications, but it's helpful to keep in mind that they work in different ways and are taken for different time periods

These are sometimes marketed as cheaper or more accessible alternatives, but quality and safety can vary

Figure 7: Obesity development landscape