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FIGURE 2 2.1.1 Calcium channel modulation Recent research has shown that exendin-4, a GLP-1RA, suppresses L-type voltage-gated calcium channels (L-VGCC) activity through a cascade involving cAMP/PKA, ryanodine receptors, and calmodulin (CaM)
Clin Ther 29(1):139153 Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH et al (2009) Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
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If you're managing other health conditions or taking other medications, talk to your doctor before starting a GLP-1 through any platform
Supplements work gradually over time
