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It signals cells to increase production of collagen, elastin, and antioxidant enzymes while suppressing certain inflammatory and tissue-destructive pathways
Once accumulates in the nucleus, -catenin acts as a transcription factor, activating a suite of genes that can disrupt cell cycle regulation, inhibit apoptosis and promote stem cell renewal and homeostasis, thereby fostering a tumorigenic environment [82, 106]
DEGseq method was used to screen for differentially expressed genes 80
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Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)
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