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The challenge remains with long-term registration trials, which are required to demonstrate that clinically beneficial outcomes are in line with FDA and EMA requirements

NHS funding and use follow the relevant NICE Technology Appraisals for type 2 diabetes and weight management, which specify eligibility criteria including BMI thresholds and required comorbidities

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This is why the exact unit calculation for your dose is not just academic

The SURMOUNT-4 trial demonstrated that participants who achieved significant weight loss on tirzepatide and then continued treatment maintained their weight loss, while those switched to placebo regained substantial weight