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Therefore, we may identify novel strategies for immunotherapeutic intervention in autoinflammatory diseases and their accompanying associated disorders by thoroughly understanding the mechanisms inherent to urate-induced dysregulation of immune cells and disease advancement

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Malfatti CR, Royes LF, Francescato L, Sanabria ER, Rubin MA, Cavalheiro EA, Mello CF (2003) Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+, K+ -ATPase activity in the rat striatum and cerebral cortex

In addition, the ICV infusion of exendin-4 increases CNS activity, promotes BAT activation and white adipose tissue browning, and increases BAT glucose and triglyceride uptake [27]