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Research has revealed that GPER activation induces AKT phosphorylation, which promotes osteoblast proliferation and differentiation, indirectly supports vitamin D metabolism and contributes to skeletal integrity [112]

Implications for clinical therapy Although, overall, both insulin sensitivity and beta-cell secretion are expected to improve with lowered glucose, HOMA-IR measurements over 8 weeks cannot be used to evaluate the effectiveness of treatment for an individual

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Taking evidence in account, more studies are necessary to go deep into the participation of oxidative stress, mitochondrial dysfunction and inflammatory response in the development of PDN

Fu Z, Xin X, Zhan Y, et al