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Mouse husbandry For the isolation of mitochondria and proximal tubular cells, kidneys were excised from cadavers of 812-week-old male and female wild type C57/BJ and C57/BJ crossed with 129S6 used for other experimental purposes not related to this study, following the principles of the 3Rs (Replacement, Reduction and Refinement) of animal experimentation
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Conclusion: In subjects with obesity and high ALT, semaglutide 0.2-0.4 mg daily reduced ALT to an extent that was broadly comparable across weight loss categories, and resulted in dose-related ALT normalization in up to 46% of subjects after 52 weeks
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