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Toxic levels of methotrexate can be rapidly and effectively decreased by intravenous administration of glucarpidase, which has been shown to induce a 99% or greater sustained reduction of serum methotrexate levels (Widemann 2014)
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In a diseased intestine, these bacteria are often not present in adequate amounts and/or have been replaced by pathogenic organisms
Complete, consistent darkness whenever the vial is in storage
(2) Add 300 L of protein precipitant methanol-acetonitrile (V:V=2:1, containing mixed internal standard, 4 g/mL), vortex and shake for 1 min
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