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In an experimental study conducted by Noyan-Ashraf and colleagues, Liraglutide upregulated the independent expression of cardioprotective genes, including Akt, PPAR-, Nrf-2, and HO-1, while suppressing the expression of GSK3 and activation of caspase-3 in murine hearts [56]
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Berberine's glucose and lipid effects appear at 900 to 1,500 mg daily in divided doses, a range replicated across multiple meta-analyses (Liang et al., 2019, 28 trials, 2,313 patients)
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