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Whilst injection site bruising can be concerning for patients, it typically resolves within 714 days without specific treatment and does not affect the medication's effectiveness

Some patients notice appetite changes within the first one to two weeks

Notwithstanding, previous studies have documented beneficial effects of the activation of estrogen receptors in diet-induced obese females, by reducing body weight and fat accumulation and improving leptin resistance at central level 53,54

Correspondingly, left ventricular internal dimensions and end volume in the HUA group were decreased compare with those in the blank group, but LC intervention ameliorated the HUA-associated decrease in internal dimensions and end volume in diastolic-stage rather than systolic-stage, as did the urate-lowering agent AP, while TMZ did not show significant improvement (Figures 6FI)