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Limitations Direct trial evidence is in HIV-associated populations
doi: 10.1038/s41581-023-00694-0 133 LiuXXieXRenYShaoZZhangNLiLet al
Also, semaglutide costs can add up quickly if your insurance doesn't cover it
The 2021 STEP 4 trial, published in JAMA, showed that people who continued semaglutide after an initial 20-week run-in kept losing weight, while those who switched to placebo regained nearly 7% of their body weight, confirming that ongoing treatment is key to maintaining results
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