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An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]
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These compounds influence biological processes such as hormone signaling, metabolism, and cellular repair
People with methionine deficiency may have poor detoxification of xenobiotics and sulfhydryl reactive metals (mercury, lead, arsenic, and cadmium), or present with fatty liver or biliary insufficiency occlusive arterial disease
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