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and increased hydrolysis of MTXPGs by lysosomal gamma-glutamyl hydrolases (GGH) (2325), although the influence of GGH on MTX efficacy remains controversial (2628)

Creatine May reduce the methyl-group demand required for endogenous creatine synthesis, preserving SAM for other reactions

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(See all compounds classified as Enzyme Inhibitors.) V03AB17 V - Various V03 - All other therapeutic products V03A - All other therapeutic products V03AB - Antidotes V03AB17 - Methylthioninium chloride V - Various V04 - Diagnostic agents V04C - Other diagnostic agents V04CG - Tests for gastric secretion V04CG05 - Methylthioninium chloride Route of Elimination Excreted in urine and bile