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"Environment also plays a role as overexposure to food messages through media and advertising can keep food at the top of mind, thus reinforcing habit loops common in obesity

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Efficacy differences: In the SURMOUNT-5 trial, tirzepatide achieved ~20% weight loss vs

The tri-agonist was tenfold more active than individual native hormones at all three receptors in vitro, and was more effective than a GLP-1R/GIPR co-agonist at lowering body weight in DIO mice [92]