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GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production

Under clinical investigation for obesity and metabolic dysfunction

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Novel interventions, including inhibition of neutrophil extracellular traps (NETs) to mitigate chronic inflammation (41) and chimeric antigen receptor - regulatory T cells (CAR-Treg cell) therapies aimed at fibrosis suppression, show promise in preclinical models but require thorough validation in clinical trials (42)

Commonly reported side effects include nausea, decreased appetite, stomach upset, and mild diarrhea