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Strikingly, the CCR8-specific viral chemokine antagonist MC148, with a reported affinity similar to CCL1 61,62 , has a short N-terminus of only 5 amino acids, which contains a triplet of basic residues (Supplementary Fig

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Its superoxide-mediated oxidation generates the fluorescent product 2-hydroxyethidium (2-E + OH) ( excitation = 500 nm, emission = 600 nm), while other ROS or reactive nitrogen species (RNS) do not form the same fluorescent product when reacting with DHE (Zhao et al., 2003