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Although the enzymes of the pathway are found at multiple locations within the cell, there is as yet little convincing evidence that they operate in the apoplastic space (Foyer and Kunert 2024)

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pylori, the formed glutamate can be taken up and converted to 2-ketoglutarate by the bacteria and channeled into the TCA cycle 21,29 , an important metabolic pathway that provides precursors for a variety of cell components, as well as for supplying energy to the bacterium 31

In PC12 cells, Pae also inhibits erastin-induced ferroptosis, alleviates oxidative damage, and lowers ROS levels

Although cream formulations are relatively safe, they may still cause adverse reactions such as skin allergy and irritation