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First isolated from human plasma by Loren Pickart in 1973, it was identified as the factor in young blood that stimulated aged liver tissue to synthesize proteins at a rate matching younger tissue [1]
Therefore, therapy primarily focuses on providing patients with supportive care to manage their symptoms using dietary supplements [9]
Chen P, Miller PD, Delmas PD, Misurski DA, Krege JK
Cognitive manifestations include depression, irritability, and anxiety, while GI manifestations encompass constipation, dysphagia, nausea, and prolonged intestinal transit time (Pfeiffer, 2003
NO plasma concentration was measured by the Griess reaction as NO 2 concentration after NO 3 reduction to NO 2 as currently performed in our laboratory [20]
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