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85 The conflicting triangle framework highlights a context-dependent interplay in which tumor cell-intrinsic immune checkpoint signaling remodels the TME via EMT induction and autophagy-mediated immune regulation, contributing to immune evasion and resistance

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And here is the important part: if you miss two or more consecutive doses, you may need to restart the full titration schedule from 0.25 mg to avoid severe gastrointestinal side effects

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