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Some studies have also demonstrated that in the cardiovascular disease aortic dissection (AD), the downregulation of P300 levels promotes the binding of p53 to HIF-1, thereby upregulating the expression level of HMOX1 and exacerbating ferroptosis[133]
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The Institute of Medicine reports that no adverse effects have been associated with excess vitamin B12 intake from food, supplements, or injections in healthy individuals. Nevertheless, its crucial to consult a professional before beginning any high-dosage supplement
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