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It is also noteworthy that the combination of MCT4 inhibitors with anti-PD-1 immunotherapy significantly improved the outcome of HCC patients (137)
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Sterile preparation
To evaluate the effect of CI inhibition on growth, organoids were seeded as fragments in Matrigel and treated the following day with water (CTRL), 5 M 5FU, 3 mM metformin or a combination of 5FU and metformin for 72 h
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