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GLP-1 agonists activate receptors in the brain's appetite centres, reducing hunger and increasing satiety, whilst also slowing gastric emptying to prolong fullness after meals, collectively leading to reduced food intake and weight loss
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Between the two, semaglutide and tirzepatide consistently lead the clinical data, and the right choice usually depends on BMI, metabolic history, and how the body responds to the starting dose
However, most low B12 levels are more caused by pernicious anaemia
