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Sci Rep 4 , 6698 (2014)
Neuropharmacology 46 , 404411 (2004)
Additionally, Candida albicans secretes aspartyl proteinases (SAPs) that degrade mitochondrial structural and metabolic proteins, further impairing mitochondrial integrity and energy production ( Cryptococcus neoformans utilizes a polysaccharide capsule to suppress mitochondrial metabolism in macrophages, decreasing mtROS production and blunting fungicidal activity ( 4.2 Fungal-mediated disruption of mitochondrial bioenergetics and ETC function Mitochondrial OXPHOS serves as a key energy source for immune cell function, particularly for macrophages and dendritic cells engaged in antifungal defense
This rapid metabolism is one reason why peptides are often administered more frequently than other types of drugs
This stability allows researchers to investigate both oral and parenteral administration routes in animal-model designs, an unusual flexibility among peptide research compounds
