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Dirnagl, U., Iadecola, C., & Moskowitz, M
The Drug Resistance Crisis Why New Options Matter Why We Urgently Need New Gonorrhea Medication Neisseria gonorrhoeae has earned its reputation as a superbug by systematically developing resistance to every antibiotic class introduced over the past century, making the December 2025 approval of zoliflodacin and gepotidacin a critical turning point in the battle against drug resistant gonorrhea. The Antibiotic Resistance Timeline 1940s: Penicillin became the first effective gonorrhea cure, providing near-100% success rates for two decades before widespread resistance emerged. 1970s-1980s: As penicillin resistance spread globally, healthcare providers shifted to tetracyclines and spectinomycin, only to see Neisseria gonorrhoeae treatment options narrow again within years. 1990s-2007: Fluoroquinolones like ciprofloxacin offered hope as oral gonorrhea antibiotics, but the CDC discontinued fluoroquinolone recommendations in 2007 after surveillance data revealed alarming resistance rates approaching 100% in some regions. 2010-present: Ceftriaxone injections combined with azithromycin became the last-resort standard for gonorrhea treatment, leaving virtually no backup options when resistance develops. The World Health Organization designated Neisseria gonorrhoeae as a high-priority pathogen in 2017 due to multidrug resistance affecting penicillin, tetracyclines, macrolides, sulphonamides, quinolones, and now emerging resistance to extended-spectrum cephalosporins
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Exceptional Cases to Avoid Shots People with kidney problems, iron deficiencies, or known sensitivities/allergies to vitamin B12 should not get B12 injections since side effects could be more likely
These were serious enough to interfere with daily functions and turn gym activity into hell
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