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The combined activation of all three pathways is hypothesised to produce more pronounced and sustained weight reduction, though the long-term clinical implications of each receptor's contribution remain to be fully established

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But it also contributes to cellular growth, which is why it has become a drug target of interest among cancer scientists: GHRH and its receptors are expressed not only in the hypothalamus and pituitary but also in peripheral tissues

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J Headache Pain 22(1):55 Zielman R, Wijnen JP, Webb A et al (2017) Cortical glutamate in migraine