dpp 4 inhibitor with glp 1 Cardiovascular effects of DPP-4 inhibition: Beyond GLP-1 Design principles of long-acting DPP-4

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Of note, non-neuronal cells of various tissues and organ systems also synthesize and release acetylcholine, which then binds and stimulates cholinergic receptors on target cells (reviewed in 6)

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Joyner S, Lee D, Hay P, Lau R

The defining feature of this molecule is the unusual gamma-peptide linkage between glutamate and cysteine, which protects the compound from being rapidly degraded by standard intracellular peptidases