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Taken together, these findings suggest that NSBSO-induced GSH depletion and synthesis inhibition can elevate intracellular ROS, thereby activating the caspase family, leading to GSDME cleavage and cell pyroptosis
C/EBP, CCAAT/enhancer binding protein
Glutathione is a natural antioxidant found in every human cell composed of three amino acids: glutamate, cysteine, and glycine
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