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Available online at: 12 MadsenLWKnaufJAGotfredsenCPillingASjgrenIAndersenSet al

A 0.16 mg dose was administered to humans in the phase 1b trial [3] , but only in combination with semaglutide 2.4 mg, so it does not establish 0.25 mg as an evidenced monotherapy step

The existing pattern across the GLP-1 class is that the weight-loss curve is driven hardest during titration and the first several months at target dose, and that once the primary loss is achieved, maintenance becomes a separate problem with a different tolerability budget

Guests have also mentioned similar benefits shown in animal trials

Variants in GIPR (rs1800437) can inform discussions with your provider about individual tolerance thresholds