As E2 and E3 mice are known to have increased longevity relative to E4 mice (Shinohara et al., 2020), this overall increase in cerebrovascular acylcarnitines could represent compensatory changes to supplement energetics with age, or act as a FA detoxification mechanism, a response which appears blunted in E4s
It works at the fat cell level, mobilizing stored triglycerides without changing how much you eat
Generally, I use it in the penultimate step of my daily skincare routine, just before a moisture or daily sunscreen
It is important to frame these accurately: this body of work is laboratory and animal-model research
Ghrelin acts on a third, separate receptor the growth hormone secretagogue receptor (GHS-R1a) and does two things: it directly stimulates GH release, *and* it suppresses somatostatin