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1 Deficiency is often due to a lack of B12 foods in the diet, absorption issues, and/or genetic mutations that affect uptake
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Therefore, the acidic residues of p53 TAD appear to have no significant impact on its interaction with the FOXO4 FHD, as these residues primarily contribute to DNA selectivity rather than binding to the FOXO4 FHD
Phase 2 trials used subcutaneous 1 mg/day
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