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In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14
GAS6/AXL signaling pathway The GAS6/AXL axis, a key member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family, is frequently overactivated in solid tumors and is strongly associated with therapy resistance
Goldfarb S., Pugh T
It is found in every cell of the body and serves as the first line of defense, with particularly high levels in the liver, kidneys, lungs, adrenal glands, reproductive organs, brain and pancreas
10.1158/2159-8290.CD-14-0250 322 YeJ.MancusoA.TongX.WardP
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