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Klotho is predominantly expressed in the kidneys and is involved in promoting antioxidant defense functions by increasing the expression of superoxide dismutase, thus reducing the levels of ROS and preventing oxidative damage in the kidneys and heart
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Garcinia cambogia is a fruit-derived supplement taken to boost weight loss, though studies disagree on its effectiveness
96 Meanwhile, high glucose and inflammation block LKB1 recruitment, activate PP2A/C, and induce degradation of AMPK catalytic subunits through the E3 ubiquitin ligase
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