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And the combination can lead to dehydration and electrolyte imbalances if vomiting or diarrhea becomes persistent, which creates secondary risks for kidney function and overall metabolic stability
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J
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Importantly, there is evidence that the effects of both medications varies by disease stage [47, 48], although results from real-world studies of SGLT2is support their effectiveness on cardiovascular and kidney outcomes in broader populations [49, 50]
543 In addition, BM-MSCs also attenuated hepatic fibrosis by secreting IL-4 and IL-10 to promote macrophage phenotypic switch from profibrotic Ly6C hi subset to restorative Ly6C lo subpopulation, which significantly blocked the source of fibrogenic cytokines (TGF-, PDGF, TNF-, and IL-1) from Ly6C hi macrophages
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