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A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization
Controlled addition of ROS, typically 1050 M H 2 O 2 , to in vitro oocyte cultures is a widely used method for modeling oxidative stress [83]
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However, more research is necessary to further characterize this relationship
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