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doi: 10.1371/JOURNAL.PONE.0016393 227 SpanogiannopoulosP.BessE

1985 Dec 7;291(6509):1601-5 Chen C, Tao C, Liu Z, et al

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No peer-reviewed study has tested any pairwise combination of the three

No antibody formation When the immune system recognizes a foreign protein and produces antibodies against it, this can reduce the compound effectiveness over time and potentially cause allergic reactions