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Oxidative stress occurs when there is an imbalance between excessive reactive oxygen species (ROS) production and/or diminished cellular antioxidant defenses

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They no longer fit melanocortin receptors and cannot trigger the intended signaling cascade

This happens because certain MTHFR mutations (C667T and A129C) lower the amount of active folate being produced in the body, and the use of vitamin B12 requires the active form of folate

For Wegovy pill based on baseline body weight of 235 lb., and for placebo based on baseline body weight of 231 lb