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H., Lim, A
In PIONEER 6, unadjudicated DRP occurred in 5.8% of oral semaglutide-treated patients and in 4.8% of the placebo-treated patients ( Villsbol and colleagues further investigated the DRP signal in the SUSTAIN program (122)
For glycemic control, the mean reduction in HbA1c across most T2DM subgroups approaches or reaches the commonly referenced threshold for clinical relevance of 0.5% 47 , and in key target populations (e.g., T2DM with obesity) can reach 0.81.0%, indicating clinically perceptible improvements
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