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Abbreviations 5-HT: 5-hydroxytryptamine, serotonin ACACA: Acetyl-CoA carboxylase alpha Acox1: Acyl-CoA oxidase 1 Adipoq: Adiponectin Agpat1: 1-acylglycerol-3-phosphate O-acyltransferase 1 Akt: Protein kinase B ASC: Apoptosis-associated speck-like protein containing a caspase-recruitment domain Atgl: Adipose triglyceride lipase CD36: Cluster of differentiation 36 Cidea: Cell deathinducing DFFA-like effector A Cpt1a: Carnitine palmitoyl transferase 1a Dgat: Diacylglycerol O-acyltransferase Dio2: Iodothyronine deiodinase 2 eIF2: Eukaryotic translation initiation factor 2 ER: Endoplasmic reticulum FABP: Fatty acid binding protein FAS: Fatty acid synthase FATP5: Fatty acid transport protein 5 F4/80: Adhesion G-protein-coupled receptor E1 FSP27: Fat-specific protein 27 GTT: Glucose tolerance test HDL: High-density lipoprotein HFD: High-fat diet HRP: Horseradish peroxidase HSL: Hormone-sensitive lipase HTR: 5-hydroxytryptamine receptor IL: Interleukin LDL: Low-density lipoprotein LPL: Lipoprotein lipase MCP-1: Monocyte chemoattractant protein-1 Mogat1: Monoacylglycerol O-acyltransferase 1 NAFLD: Nonalcoholic fatty liver disease NLRP3: NOD-like receptor family pyrin domain containing 3 PERK: Protein kinase R-like endoplasmic reticulum kinase PGC1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PLIN1: Perilipin 1 PPAR: Peroxisome proliferator-activated receptor SCD: Standard chow diet SCD-1: Stearoyl-CoA desaturase-1 SREBP: Sterol regulatory element-binding protein TNF: Tumor necrosis factor UCP: Uncoupling protein WAT: White adipose tissue References Powell EE, Wong VW-S, Rinella M

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It targets the MC1R receptor and focuses on photoprotective pigmentation, while possessing a well-studied safety profile

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