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These results may inform research into psychiatric safety and potential repurposing opportunities for GLP-1RAs, especially in people with mental health disorders, but randomized clinical trials are needed to determine whether the genetic associations translate into treatment benefits

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GLP-1 actions in the control of food intake A number of peptide hormones, previously thought to be specific to the gastroenteropancreatic system and later found also in the mammalian brain, have been shown to modulate appetite, energy homeostasis and body weight

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