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The results of a trial funded by Eli Lilly (the drugs manufacturer) and published in the New England Journal of Medicine (NEJM) found 85% of those on the lowest dose of Mounjaro and 91% on the highest dose lost at least 5% of their total body weight
In the meantime, the GLP-1 discontinuation wave from Semaglutide and Tirzepatide alone is already creating significant downstream demand, for metabolic support products, muscle preservation, and micronutrient replenishment
For example, Mendelian randomization analysis using genetic instrumental variables was used to help validate some of the derived proteomic signatures for specific traits
The two component drugs also have FDA approval for other purposes and are available as inexpensive generic medications, so they can be prescribed separately and taken together
Some healthcare providers recommend tapering with lower doses before stopping completely
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