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This could be due to racial differences in B12 metabolism, or in environmental factors, most obviously diet (B12 intake)

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A targeted analysis was performed using isotopically labeled internal standards for L-carnitine, -BB, TMA, and TMAO

These results indicate that the authors have successfully demonstrated for the first time that engineered M2 macrophage membranes encapsulating PROTAC-PEM can be applied to AS treatment by targeting the degradation of METTL4 in macrophages [138]