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As a result, there is upregulation of genes involved in lipid and glucose uptake, inhibition of lipolysis, and mitochondrial dysfunction, which collectively contribute to fat accumulation and metabolic alterations in the affected areas.15,16 Furthermore, gene expression studies show increased aromatase CYP19A1 the enzyme that converts androgens to estrogen in lipedema subcutaneous fat compared to healthy controls and even to the abdominal fat of the same patient

As an incretin based research compound, retatrutide is often discussed alongside other peptide agonists used to probe endocrine signaling and cardiometabolic biomarkers

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