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### Semaglutide Mechanism of Action Semaglutide achieves **weight loss** through multiple complementary pathways: - **Central appetite suppression** acts on hypothalamic GLP-1 receptors to reduce hunger and increase satiety - **Delayed gastric emptying** slows stomach emptying, prolonging feelings of fullness - **Improved insulin sensitivity** reduces insulin resistance and promotes healthy glucose metabolism - **Reward pathway modulation** reduces cravings and food-seeking behavior by acting on mesolimbic dopamine circuits - **Potential direct effects on adipose tissue** emerging research suggests GLP-1 may directly influence fat metabolism For a complete breakdown of semaglutide's dosing protocol, see our [semaglutide dosing schedule week-by-week guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)
Cycle length: 8 to 16 weeks on, followed by 4 to 8 weeks off
When combined strategically, they can create a more comprehensive approach to recovery
Tissue Repair: Both peptides demonstrate wound-healing, tendon-repair, and anti-inflammatory properties in animal models [1] [3] [10]
In adults, deficiency may cause megaloblastic anaemia , leading to weakness and fatigue
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