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Systemic corticosteroids (prednisone) may be used for more extensive disease, though they are not appropriate for maintenance due to significant adverse effects with prolonged use
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Cancer Risk Elevated levels of insulin-like growth factor-1 (IGF-1), which is the downstream effect of GH activity, have also raised theoretical concerns about an increased risk of cancer: According to Roberts, IGF-1 promotes cellular proliferation and inhibits apoptosis, two mechanisms that may contribute to the development of cancer cells in predisposed individuals (22)
GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]
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