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A key mechanism involves their interaction with glial cells, as recent studies show that activated microglia and astrocytes can induce the expression of GLP-1 R, making them direct targets for GLP-1 mimetics [41]
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Statements Author contributions TD: Conceptualization, Investigation, Data curation, Visualization, Writingoriginal draft, Writingreview and editing
Interestingly, IDO1 is closely associated with chronic inflammatory responses [61, 62] and increased IDO1 activity through upregulation, then alters the ratio between kynurenine and tryptophan [63]
